US Patent Issued to IFOM -FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE, IEO-ISTITUTO EUROPEO DI ONCOLOGIA on Sept. 2 for "HECT E3 ligase inhibitors and uses thereof" (Italian Inventors)

ALEXANDRIA, Va., Sept. 3 -- United States Patent no. 12,403,144, issued on Sept. 2, was assigned to IFOM -FONDAZIONE ISTITUTO FIRC DI ONCOLOGIA MOLECOLARE (Milan) and IEO-ISTITUTO EUROPEO DI ONCOLOGIA S.R.L. (Milan).

"HECT E3 ligase inhibitors and uses thereof" was invented by Sebastiano Pasqualato (Milan), Maurizio Pasi (Torre d'Isola, Italy), Raffaella Amici (Codogno, Italy), Mario Varasi (Milan), Ciro Mercurio (Legnano, Italy), Luca Sartori (Milan), Simona Polo (Milan), Elena Maspero (Milan) and Giovanni Faga' (Milan).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to tricyclic derivatives of formula (I), which are useful as inhibitors of HECT-domain-containing E3 ligases, in p...