ALEXANDRIA, Va., June 9 -- United States Patent no. 12,286,481, issued on April 29, was assigned to Horizon Therapeutics Ireland DAC (Dublin).

"Methods for the treatment of thyroid eye disease" was invented by David Madden (Mount Kisco, N.Y.), Kathleen Gabriel (Voorhees, N.J.), Guido Magni (Basel, Switzerland) and Richard Woodward (Phoenixville, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention provides a method of reducing the severity of, or treating, thyroid-associated ophthalmopathy (TAO), also known as thyroid eye disease (TED) or Graves' ophthalmopathy or orbitopathy (GO), as well as antibodies, or antigen binding fragments thereof, and pharmaceutical compositions comprising them, useful...