US Patent Issued to HEPAREGENIX on Nov. 11 for "3-benzoyl-1H-pyrrolo[2,3-bpyridine derivatives as MKK4 inhibitors for treating liver diseases" (German Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,466,826, issued on Nov. 11, was assigned to HEPAREGENIX GMBH (Tubingen, Germany).

"3-benzoyl-1H-pyrrolo[2,3-bpyridine derivatives as MKK4 inhibitors for treating liver diseases" was invented by Roland Selig (Munich), Stefan Laufer (Tubingen, Germany) and Wolfgang Albrecht (Ulm, Germany).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to compounds of formula (I) which are inhibitors of MKK4 (mitogen-activated protein kinase kinase 4) and their use in promoting liver regeneration or reducing or preventing hepatocyte death. The compounds selectively inhibit protein kinase MKK4 over protein kinases JNK1 and MKK7. In formula (I), especial...