US Patent Issued to Generation Bio on Sept. 16 for "Non-viral DNA vectors and uses thereof for expressing phenylalanine hydroxylase (PAH) therapeutics" (Massachusetts Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,415,002, issued on Sept. 16, was assigned to Generation Bio Co. (Cambridge, Mass.).

"Non-viral DNA vectors and uses thereof for expressing phenylalanine hydroxylase (PAH) therapeutics" was invented by Douglas Anthony Kerr (Cambridge, Mass.), Phillip Samayoa (Cambridge, Mass.), Nathaniel Silver (Cambridge, Mass.) and Matthew Chiocco (Cambridge, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The application describes ceDNA vectors having linear and continuous structure for delivery and expression of a transgene. ceDNA vectors comprise an expression cassette flanked by two ITR sequences, where the expression cassette encodes a transgene encoding PAH...