ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,227,589, issued on Feb. 18, was assigned to Forevertek Biotechnology Co. Ltd (Changsha, China) and ProMab Biotechnologies Inc. (Richmond, Calif.).
"Epcam antibody and Epcam-CAR-T cells" was invented by Lijun Wu (Berkeley, Calif.) and Vita Golubovskaya (Pinole, Calif.).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention is directed to a humanized monoclonal anti-human EpCAM antibody, such as a single-chain variable fragment (scFv), comprising VH having the amino acid of SEQ ID NO: 2 and VL having the amino acid of SEQ ID NO: 4. The present invention is also directed to a chimeric antigen receptor fusion protein comprising from N-terminus ...