US Patent Issued to F.I.S.-FABBRICA ITALIANA SINTETICI on Oct. 7 for "Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof" (Italian Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,042, issued on Oct. 7, was assigned to F.I.S.-FABBRICA ITALIANA SINTETICI S.P.A. (Montecchio Maggiore, Italy).

"Process for the preparation of key intermediates for the synthesis of Eltrombopag or salt thereof" was invented by Paolo Stabile (Montecchio Maggiore, Italy) and Floriana Semeraro (Montecchio Maggiore, Italy).

According to the abstract* released by the U.S. Patent & Trademark Office: "Object of the present invention is an improved process for the preparation of key intermediates for the synthesis of Eltrombopag, passing through/using intermediate 5'-Chloro-2'-hydroxy[1,1'-biphenyl]-3-carboxylic acid alkaline metal salt of formula: wherein A is an alkaline metal."

The pa...