US Patent Issued to Exelixis on April 15 for "Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yloxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer" (American, British Inventors)

ALEXANDRIA, Va., June 5 -- United States Patent no. 12,275,706, issued on April 15, was assigned to Exelixis Inc. (Alameda, Calif.).

"Malate salt of N-(4-{[6,7-bis(methyloxy) quinolin-4-yloxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, and crystalline forms thereof for the treatment of cancer" was invented by Adrian St. Clair Brown (Ely, Great Britain), Peter Lamb (Oakland, Calif.) and William P. Gallagher (Princeton, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed are malate salts of N-(4-{[6,7-bis(methyloxy)-quinolin-4-yl]oxy}phenyl)-N'-(4-fluorophenyl)cyclopropane-1,1-dicarboxamide, including a (L)-malate salt, a (D)-malate salt, a (DL) malate salt, and mixtures thereof; and c...