US Patent Issued to EMENDOBIO on Nov. 25 for "Differential knockout of an allele of a heterozygous ELANE gene" (Israeli Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,480,140, issued on Nov. 25, was assigned to EMENDOBIO INC. (Wilmington, Del.).

"Differential knockout of an allele of a heterozygous ELANE gene" was invented by David Baram (Tel Aviv, Israel), Lior Izhar (Tel Aviv, Israel), Asael Herman (Ness-Ziona, Israel), Rafi Emmanuel (Ramla, Israel), Michal Golan Mashiach (Ness-Ziona, Israel) and Joseph Georgeson (Rehovot, Israel).

According to the abstract* released by the U.S. Patent & Trademark Office: "Methods for inactivating in a cell a mutant allele of the elastase, neutrophil expressed gene (ELANE gene) gene having a mutation associated with severe congenital neutropenia (SCN) or cyclic neutropenia (CyN) and which cell is heterozygous at...