ALEXANDRIA, Va., June 18 -- United States Patent no. 12,325,753, issued on June 10, was assigned to Dyne Therapeutics Inc. (Waltham, Mass.).
"Method of using an anti-transferrin receptor antibody to deliver an oligonucleotide to a subject having facioscapulohumeral muscular dystrophy" was invented by Romesh R. Subramanian (Framingham, Mass.), Mohammed T. Qatanani (Waltham, Mass.) and Timothy Weeden (Waltham, Mass.).
According to the abstract* released by the U.S. Patent & Trademark Office: "Aspects of the disclosure relate to complexes comprising a muscle-targeting agent covalently linked to a molecular payload. In some embodiments, the muscle-targeting agent specifically binds to an internalizing cell surface receptor on muscle cells. In...