US Patent Issued to DNA Twopointo, The General Hospital on Sept. 23 for "Modification of CAR-T cells" (Massachusetts, California Inventors)

ALEXANDRIA, Va., Sept. 23 -- United States Patent no. 12,419,913, issued on Sept. 23, was assigned to DNA Twopointo Inc. (Newark, Calif.) and The General Hospital Corp. (Boston).

"Modification of CAR-T cells" was invented by Yifang Shui (Boston), Jeremy Minshull (Los Altos, Calif.), Maggie Lee (San Jose, Calif.), Feng Shi (Winchester, Mass.) and Mark Cobbold (Winchester, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Modified immune cells are provided, the modified immune cells expressing a heterologous polynucleotide comprising a nucleotide sequence encoding a function (e.g., at least one of persistence, proliferation, or cytotoxicity) booster, e.g., an apoptosis inhibitor. In one aspect, the modified...