US Patent Issued to DANA-FARBER CANCER INSTITUTE on June 17 for "DOT1L degraders and uses thereof" (Massachusetts Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,331,069, issued on June 17, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).

"DOT1L degraders and uses thereof" was invented by Scott Armstrong (Wayland, Mass.) and Jun Qi (Sharon, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are bifunctional compounds with a moiety or domain that is a binder of the ubiquitin receptor RPN13 and another moiety or domain that is a binder of a target protein DOT1L to induce degradation of DOT1L. Also provided are pharmaceutical compositions comprising the bifunctional compounds, and methods of treating and/or preventing diseases (e.g., proliferative diseases, such as cancers). Provided al...