US Patent Issued to DANA-FARBER CANCER INSTITUTE on June 17 for "Degradation of bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand methods of use" (American, Canadian Inventors)

ALEXANDRIA, Va., June 19 -- United States Patent no. 12,329,821, issued on June 17, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).

"Degradation of bruton's tyrosine kinase (BTK) by conjugation of BTK inhibitors with E3 ligase ligand methods of use" was invented by Nathanael S. Gray (Stanford, Calif.), Dennis Dobrovolsky (Toronto) and Hai-Tsang Huang (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides bifunctional compounds of Formula (X):or an enantiomer, diastereomer, or stereoisomer thereof, or pharmaceutically acceptable salt, hydrate, solvate, or prodrug thereof, which act as protein degradation inducing moieties for Bruton's tyrosine kinase (BTK). The pre...