US Patent Issued to DANA-FARBER CANCER INSTITUTE on June 10 for "Cyclin-dependent kinase degraders and methods of use" (Massachusetts Inventors)

ALEXANDRIA, Va., June 18 -- United States Patent no. 12,325,725, issued on June 10, was assigned to DANA-FARBER CANCER INSTITUTE INC. (Boston).

"Cyclin-dependent kinase degraders and methods of use" was invented by Nathanael S. Gray (Boston) and John Hatcher (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present application provides compounds of Formula (Ia), or an enantiomer, diastereomer, stereoisomer, or pharmaceutically acceptable salt thereof, which act as protein degradation inducing moieties for one or more of cyclin-dependent kinase 8 (CDK8) and cyclin-dependent kinase 19 (CDK19). The present application also relates to methods for the targeted degradation of CDK8 and/or CDK19 through the...