US Patent Issued to Dana-Farber Cancer Institute on July 22 for "Compositions, assays, and methods for direct modulation of fatty acid metabolism" (Massachusetts Inventors)

ALEXANDRIA, Va., July 23 -- United States Patent no. 12,366,576, issued on July 22, was assigned to Dana-Farber Cancer Institute Inc. (Boston).

"Compositions, assays, and methods for direct modulation of fatty acid metabolism" was invented by Loren D. Walensky (Newton, Mass.) and Silvia Escudero (Brookline, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure relates to the surprising and unexpected finding that the well-known cancer protein, Myeloid Cell Leukemia-1 (MCL-1), binds to and modulates the enzymatic activity of Very Long Chain Acyl CoA Dehydrogenase (VLCAD), thereby regulating fatty acid Beta-oxidation. This finding is employed in compositions and methods of treating cancer, metab...