US Patent Issued to Council of Scientific & Industrial Research on July 29 for "Cloning and expression of in vivo refolded antibody fragment" (Indian Inventors)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,482, issued on July 29, was assigned to Council of Scientific & Industrial Research (New Delhi).

"Cloning and expression of in vivo refolded antibody fragment" was invented by Rahul Sharad Bhambure (Pune, India) and Aatir Asad Tungekar (Pune, India).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention relates to a process for production and recovery of in-vivo refolded recombinant antibody fragment in a soluble form in the cytoplasm of a microbial expression system. More particularly, the present invention relates to a process for production of in-vivo refolded recombinant humanized biosimilar Ranibizumab antibody fragment in a solubl...