ALEXANDRIA, Va., June 18 -- United States Patent no. 12,324,807, issued on June 10, was assigned to Cornell University (Ithaca, N.Y.) and The Trustees of Columbia University (New York).

"Combination therapy for PI3K-associated disease or disorder" was invented by Lewis C. Cantley (Cambridge, Mass.), Benjamin Hopkins (Larchmont, N.Y.), Marcus Goncalves (Garden City, N.Y.) and Siddhartha Mukherjee (New York).

According to the abstract* released by the U.S. Patent & Trademark Office: "Described herein are compositions and methods for treating a disease or disorder associated with PI3K signaling. For example, such compositions can include use of modulators of glucose metabolism, use of at least one kinase in the insulin-receptor/PI3K/AKT/mTOR...