US Patent Issued to City of Hope on Jan. 13 for "Chimeric antigen receptors (CARs) having mutations in the fc spacer region and methods for their use" (California Inventors)

ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,522,667, issued on Jan. 13, was assigned to City of Hope (Duarte, Calif.).

"Chimeric antigen receptors (CARs) having mutations in the fc spacer region and methods for their use" was invented by Stephen J. Forman (Duarte, Calif.), Christine E. Brown (Duarte, Calif.) and Armen Mardiros (Glendale, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Chimeric antigen receptors that include an antigen recognition domain; a spacer domain derived from a modified immunoglobulin Fc region having one or more mutations in its CH2 region resulting in impaired binding to an FcR; and an intracellular signaling domain."

The patent was filed on Oct. 25, 2021, under A...