US Patent Issued to CHUGAI SEIYAKU on Nov. 25 for "Cytotoxicity-inducing therapeutic agent" (Japanese, Singaporean Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,479,915, issued on Nov. 25, was assigned to CHUGAI SEIYAKU K.K. (Tokyo).

"Cytotoxicity-inducing therapeutic agent" was invented by Shogo Kamikawaji (Kanagawa, Japan), Yasuko Kinoshita (Kanagawa, Japan) and Shinya Ishii (Singapore).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present inventors discovered novel multispecific antigen-binding molecules with excellent cellular cytotoxicity, which comprise a first domain comprising a first antigen variable region which binds to DLL3 and a second domain comprising a second antigen variable region which binds to T cell receptor complex. The present inventors prepared further bispecific antibodies, and asse...