ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,713, issued on March 18, was assigned to Cho Plus Inc. (South San Francisco, Calif.).

"Cell hybrids as virus packaging cells for high efficiency production of gene therapy vectors and viral vaccines" was invented by Lawrence Forman (San Mateo, Calif.) and Kathy Ngo (San Francisco).

According to the abstract* released by the U.S. Patent & Trademark Office: "This disclosure provides a technology for adapting host cells to maximize production and improve quality of viral vectors and particles. Cell hybrids are formed from parental cell lines, and divided or cloned into multiple aliquots for testing. Aliquots are chosen that have high production capacity and phenotypic features for ...