US Patent Issued to Children's Medical Center, The Regents of the University of California on March 18 for "Compositions and methods for inhibiting Wnt signaling" (California, Connecticut, Massachusetts Inventors)

ALEXANDRIA, Va., March 19 -- United States Patent no. 12,252,515, issued on March 18, was assigned to Children's Medical Center Corp. (Boston) and The Regents of the University of California (Oakland, Calif.).

"Compositions and methods for inhibiting Wnt signaling" was invented by Min Dong (Weatogue, Conn.), Liang Tao (Boston), Rongsheng Jin (Irvine, Calif.), Peng Chen (Oakland, Calif.) and Aina He (Boston).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are agents that bind to the lipid binding groove of Frizzled (FZD). In some embodiments, the agent is a fragment of TcdB corresponding to amino acids 1285-1804 of SEQ ID NO: 1. In some embodiments, binding of the agent to the lipid binding groo...