US Patent Issued to California Institute of Technology on Oct. 7 for "Fractional initiator hybridization chain reaction" (California Inventors)

ALEXANDRIA, Va., Oct. 8 -- United States Patent no. 12,435,359, issued on Oct. 7, was assigned to California Institute of Technology (Pasadena, Calif.).

"Fractional initiator hybridization chain reaction" was invented by Niles A Pierce (Pasadena, Calif.) and Harry M. T. Choi (Pasadena, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure relates to methods and compositions involving HCR reactions that involve initiators that are split into two or more parts. Effective HCR is dependent upon two or more of these split initiators being brought into proximity (e.g., via binding events mediated by a target) such that a full initiator is formed that is capable of triggering HCR signal ampli...