US Patent Issued to California Institute of Technology on July 15 for "Thermal control of T-cell immunotherapy through molecular and physical actuation" (California Inventors)

ALEXANDRIA, Va., July 16 -- United States Patent no. 12,359,208, issued on July 15, was assigned to California Institute of Technology (Pasadena, Calif.).

"Thermal control of T-cell immunotherapy through molecular and physical actuation" was invented by Mohamad H. Abedi (Pasadena, Calif.), Mikhail Shapiro (Pasadena, Calif.), Dan I. Piraner (Pasadena, Calif.) and Justin Lee (Pasadena, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Disclosed herein include methods, compositions, and kits suitable for use in spatiotemporal regulation of therapeutic T-cells through a combination of molecular and physical actuation. There are provided, in some embodiments, thermal bioswitches that allow T-cells to sense sm...