US Patent Issued to Bristol-Myers Squibb on Sept. 9 for "Antagonistic CD40 monoclonal antibodies and uses thereof" (American, Canadian Inventors)

ALEXANDRIA, Va., Sept. 10 -- United States Patent no. 12,409,223, issued on Sept. 9, was assigned to Bristol-Myers Squibb Co. (Princeton, N.J.).

"Antagonistic CD40 monoclonal antibodies and uses thereof" was invented by Aaron Yamniuk (Vancouver, Canada), Mary Struthers (Edison, N.J.), Stanley R. Krystek Jr. (Ringoes, N.J.), Akbar Nayeem (Newtown, Pa.) and Ginger Rakestraw (Somerville, Mass.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The disclosure provides for antibodies that bind CD40, including a humanized antibody. The antibodies bind CD40 and do not exhibit CD40 agonist activity. The antibodies may comprise a modified IgG1 Fc domain, and exhibit minimal activation of immature dendritic cells. Composi...