US Patent Issued to Boehringer Ingelheim International on May 27 for "Spiro[3H-indole-3,2'-pyrrolidin-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors" (Austrian, German Inventors)

ALEXANDRIA, Va., June 17 -- United States Patent no. 12,312,363, issued on May 27, was assigned to Boehringer Ingelheim International GmbH (Ingelheim am Rhein, Germany).

"Spiro[3H-indole-3,2'-pyrrolidin-2(1H)-one compounds and derivatives as MDM2-p53 inhibitors" was invented by Juergen Ramharter (Vienna), Joachim Broeker (Moedling, Austria), Annika Gille (Mittelbiberach, Germany), Andreas Gollner (Vienna), Manuel Henry (Schemmerhofen, Germany), Nina Kerres (Vienna) and Harald Weinstabl (Vienna).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention encompasses compounds of formula (I)wherein the groups R1 to R7, A, V, W, X, Y, n, r and q are defined in claim 1, their use as inhibitors of MDM2-p5...