US Patent Issued to Boehringer Ingelheim International on July 29 for "Method of increasing protein production in a chinese hamster ovary perfusion cell culture" (California, New Jersey Inventors)

ALEXANDRIA, Va., July 30 -- United States Patent no. 12,371,656, issued on July 29, was assigned to Boehringer Ingelheim International GmbH (Ingelheim am Rhein, Germany).

"Method of increasing protein production in a chinese hamster ovary perfusion cell culture" was invented by Samantha Wang (San Francisco) and Henry Lin (Westfield, N.J.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The invention relates to a method of culturing mammalian cells expressing a heterologous protein in a perfusion cell culture comprising increasing the potassium concentration and decreasing the molar ratio of sodium to potassium to reduce wasteful cell bleed and to increase protein production. The invention further relates to a ...