US Patent Issued to Board of Trustees of Southern Illinois University, The Royal Institution for the Advancement of Learning/McGill University on Nov. 11 for "Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions" (Canadian, American, British Inventors)

ALEXANDRIA, Va., Nov. 11 -- United States Patent no. 12,467,045, issued on Nov. 11, was assigned to Board of Trustees of Southern Illinois University (Carbondale, Ill.) and The Royal Institution for the Advancement of Learning/McGill University (Montreal).

"Tuning CRISPR/Cas9 activity with chemically modified nucleotide substitutions" was invented by Keith Gagnon (Carbondale, Ill.), Masad Damha (Montreal), Elise Malek-Adamian (Ottawa), Maryam Habibian (Montreal), Daniel O'Reilly (Waterlooville, Great Britain) and Zachary Kartje (Valparaiso, Ind.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides CRISPR/Cas9 ribonucleoprotein compositions comprising chemically modified CRISPR RNA (...