ALEXANDRIA, Va., July 16 -- United States Patent no. 12,357,659, issued on July 15, was assigned to BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM (Austin, Texas).

"Production of megakaryocytes or platelets from monocytes" was invented by Zeev Estrov (Houston), Srdan Verstovsek (Houston), Taghi Manshouri (Houston) and Ivo Veletic (Houston).

According to the abstract* released by the U.S. Patent & Trademark Office: "We disclose a method, comprising extracting cells from a tissue of a donor, wherein the tissue is selected from the group consisting of blood and bone marrow; isolating CD14+ monocytes from the extracted cells; culturing the isolated CD14+ monocytes; differentiating the cultured CD14+ monocytes into megakaryocytes; and admini...