US Patent Issued to Board of Regents, The University of Texas System on Aug. 5 for "Histone demethylase inhibitors for treating cancers" (Texas Inventors)

ALEXANDRIA, Va., Aug. 6 -- United States Patent no. 12,378,201, issued on Aug. 5, was assigned to Board of Regents, The University of Texas System (Austin, Texas).

"Histone demethylase inhibitors for treating cancers" was invented by Jer-Tsong Hsieh (Plano, Texas), Jung-Mo Ahn (Plano, Texas) and Zhi-Ping Liu (Dallas).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides a new series of 8-hydroxyquinoline derivatives/analogs that are potent KDM4 inhibitors with high activity and selectivity against KDM4 enzymes. Also disclosed are the pharmaceutical compositions comprising such 8-hydroxyquinoline-based potent KDM4 inhibitors, or a pharmaceutically acceptable salt thereof, and method of...