ALEXANDRIA, Va., Aug. 20 -- United States Patent no. 12,391,915, issued on Aug. 19, was assigned to BioLamina AB (Stockholm).
"Maintenance of differentiated cells with laminins" was invented by Karl Tryggvason (Singapore), Karl Kristian Tryggvason (Stockholm) and Anna Domogatskaya (Ronninge, Sweden).
According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure describes methods of maintaining the phenotype of differentiated cells. Generally, the natural environment of the body is replicated for the differentiated cell. The differentiated cell is plated on a cell culture substrate comprising a laminin, such as laminin-521 or laminin-511. The substrate may also contain a cadherin. This maintains the phe...