US Patent Issued to Baylor College of Medicine, Texas Heart Institute on Nov. 25 for "Hippo and dystrophin complex signaling in cardiomyocyte renewal" (Texas Inventors)

ALEXANDRIA, Va., Nov. 25 -- United States Patent no. 12,480,120, issued on Nov. 25, was assigned to Baylor College of Medicine (Houston) and Texas Heart Institute (Houston).

"Hippo and dystrophin complex signaling in cardiomyocyte renewal" was invented by James F. Martin (Pearland, Texas), Yuka Morikawa (Houston), Todd Ryan Heallen (Houston) and John P. Leach (Pearland, Texas).

According to the abstract* released by the U.S. Patent & Trademark Office: "Embodiments of the disclosure include methods and compositions for the renewal of cardiomyocytes by targeting the Hippo pathway. In particular embodiments, an individual with a need for cardiomyocyte renewal is provided an effective amount of a shRNA molecule that targets the Sav1 gene. Par...