US Patent Issued to Ascidian Therapeutics, The Trustees of the University of Pennsylvania on Oct. 14 for "Trans-splicing molecules" (Pennsylvania, New Jersey, North Carolina Inventors)

ALEXANDRIA, Va., Oct. 21 -- United States Patent no. 12,442,003, issued on Oct. 14, was assigned to Ascidian Therapeutics Inc. (Boston) and The Trustees of the University of Pennsylvania (Philadelphia).

"Trans-splicing molecules" was invented by Philip R. Johnson (Bryn Mawr, Pa.), Bruce C. Schnepp (Havertown, Pa.), Jean Bennett (Bryn Mawr, Pa.), Scott J. Dooley (Clementon, N.J.), Krishna Jawaharlal Fisher (Durham, N.C.) and Junwei Sun (Philadelphia).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention features nucleic acid trans-splicing molecules (e.g., pre-mRNA trans-splicing molecules (RTMs)) capable of correcting one or more mutations in the ABCA4 gene or the CEP290 gene. Such molecules ar...