ALEXANDRIA, Va., Jan. 13 -- United States Patent no. 12,521,386, issued on Jan. 13, was assigned to Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Ariz.).

"Small molecule inhibitors of the androgen receptor activity and/or expression and uses thereof" was invented by Christopher Hulme (Tucson, Ariz.), Yeng-Jeng Shaw (Tucson, Ariz.) and Vijay Gokhale (Tucson, Ariz.).

According to the abstract* released by the U.S. Patent & Trademark Office: "This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a piperazine (or similar) structure which function as antagonists of androgen receptor activity, and their use as therapeutics for the treatment...