US Patent Issued to Arizona Board of Regents on Behalf of the University of Arizona on Feb. 18 for "Nitroreductase-releasable pro-drugs and methods for using the same" (Arizona Inventors)

ALEXANDRIA, Va., Feb. 19 -- United States Patent no. 12,226,488, issued on Feb. 18, was assigned to Arizona Board of Regents on Behalf of the University of Arizona (Tucson, Ariz.).

"Nitroreductase-releasable pro-drugs and methods for using the same" was invented by Eugene A. Mash (Tucson, Ariz.) and Pawel R. Kiela (Tucson, Ariz.).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present invention provides a nitroreductase-releasable pro-drug of the formula:where Ar1, m, n, Z, Y, L, and A are as defined herein, and methods for using and producing the same. Compound of formula I is useful in oral administration of the active pharmaceutical ingredient to the distal gut region of a subject to treat a wide variet...