US Patent Issued to Amicus Therapeutics on Sept. 16 for "Augmented acid alpha-glucosidase for the treatment of Pompe disease" (Pennsylvania, New Jersey Inventors)

ALEXANDRIA, Va., Sept. 17 -- United States Patent no. 12,414,985, issued on Sept. 16, was assigned to Amicus Therapeutics Inc. (Philadelphia).

"Augmented acid alpha-glucosidase for the treatment of Pompe disease" was invented by Hung V. Do (New Hope, Pa.), Richie Khanna (Somerset, N.J.) and Russell Gotschall (Doylestown, Pa.).

According to the abstract* released by the U.S. Patent & Trademark Office: "A method for treating Pompe disease including administration of recombinant human acid Alpha-glucosidase having optimal glycosylation with mannose-6-phosphate residues in combination with an amount of miglustat effective to maximize tissue uptake of recombinant human acid Alpha-glucosidase while minimizing inhibition of the enzymatic activit...