US Patent Issued to Amgen on June 10 for "Total afucosylated glycoforms of antibodies produced in cell culture" (California Inventors)

ALEXANDRIA, Va., June 18 -- United States Patent no. 12,325,737, issued on June 10, was assigned to Amgen Inc. (Thousand Oaks, Calif.).

"Total afucosylated glycoforms of antibodies produced in cell culture" was invented by Prince Bhebe (Thousand Oaks, Calif.), Matthew Jerums (Thousand Oaks, Calif.), Irene Liu (Thousand Oaks, Calif.) and Kurt Kunas (Thousand Oaks, Calif.).

According to the abstract* released by the U.S. Patent & Trademark Office: "Provided herein are methods of producing an antibody composition comprising a desired or predetermined or pre-selected level of total afucosylated (TAF) glycoforms. In exemplary embodiments, the method comprises maintaining glycosylation-competent cells in a cell culture medium comprising fucose ...