ALEXANDRIA, Va., Dec. 9 -- United States Patent no. 12,491,192, issued on Dec. 9.

"Compositions and methods for the topical administration of spironolactone for the treatment of cutaneous signs of excess androgen and chronic stress response" was invented by Amy Thorne (Ardmore, Okla.) and Tien Viet Nguyen (Seattle).

According to the abstract* released by the U.S. Patent & Trademark Office: "The present disclosure provides methods for treating or alleviating symptoms of a disease, disorder, or condition related to excess androgen or stress-induced skin changes in a subject in need thereof by topically administering a pharmaceutical composition comprising a pharmaceutically effective amount of spironolactone to the subject. Other aspects re...