International Clinical Trial: A Prospective Clinical Study to Evaluate the Efficacy and Safety of a Novel Y-shaped Layered Anti-reflux Anastomosis in esophagectomy(YES Trial)

Geneva, Jan. 12 -- International Clinical Trials Registry received information related to the study (ChiCTR2500114874) titled 'A Prospective Clinical Study to Evaluate the Efficacy and Safety of a Novel Y-shaped Layered Anti-reflux Anastomosis in esophagectomy(YES Trial)' on Dec. 18, 2025.

Study Type: Interventional study

Study Design: Parallel

Primary Sponsor: The First Affiliated Hospital of Zhengzhou University

Condition: Esophageal carcinoma

Intervention: Cohort A:Y-shaped hand-sewn layered anti-reflux anastomosis:Y-shaped hand-sewn layered anti-reflux anastomosis. The adventitia and muscular layer of the esophagus, as well as the seromuscular layer of the gastric tube, are manually stripped. An end-to-side anastomosis is then...