Clinical Trial: A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases

U.S., Dec. 6 -- ClinicalTrials.gov registry received information related to the study (NCT07268053) titled 'A Phase 0/1 Clinical Trial With an Expansion Phase of GSK5764227, a B7-H3-Targeted Antibody-Drug Conjugate (ADC), in Patients With Recurrent Grade 4 Glioma and Patients With Brain Metastases' on Nov. 24.

Brief Summary: This will be an open-label Phase 0/1 study that will enroll approximately 15 participants, 9 participants with recurrent WHO Grade 4 glioma (rGBM) and 6 participants with brain metastases, who will receive the investigational drug GSK5764227, a B7-H3-targeted antibody-drug conjugate (ADC) with the GSK5757810 payload.

The trial will consist of a Phase 0 component (subdivided into Arms A and B) and an Expansion Phase 1 ...