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Singapore Clinical Trial: TulmiSTAR-01: A two-part, Phase I dose escalation and expansion followed by a randomized, open-label multicenter, Phase II study to assess the safety and efficacy of the combination of tulmimetostat (DZR123) and JSB462 (luxdegalutamide) vs standard of care in patients with progressive metastatic castrate resistant prostate cancer

Singapore, May 22 -- The Health Sciences Authority received information related to the study titled 'TulmiSTAR-01: A two-part, Phase I dose escalation and expansion followed by a randomized, open-labe... Read More


Singapore Clinical Trial: A Master Protocol of an Open-Label, Multi-Drug, Multi-Centre, Phase II Study to Evaluate the Safety, Tolerability, Pharmacokinetics, Immunogenicity, and Antitumour Activity of Novel Combinations in Participants with Locally Advanced or Metastatic Non-Small Cell Lung Cancer (LIBRA)

Singapore, May 22 -- The Health Sciences Authority received information related to the study titled 'A Master Protocol of an Open-Label, Multi-Drug, Multi-Centre, Phase II Study to Evaluate the Safety... Read More


Clinical Trial: Comparative evaluation of two different drugs administered using the transdermal drug delivery route versus two oral tablets in the management of postendodontic pain: A randomized controlled clinical trial (Japan)

Tokyo, May 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061652) titled 'Pain Relief Patch Versus Oral Tablet After Root Canal Treatment' on May 22. ... Read More


Clinical Trial: Effects of Morning Cheese Intake and Light Exposure on Sleep and Activity Rhythms, Health, and Developmental Outcomes in Preschool Children: A Chrononutritional Intervention Study (Japan)

Tokyo, May 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061651) titled 'Effects of Morning Cheese Intake and Morning Light Exposure on Sleep and Dai... Read More


Clinical Trial: Comparison of The Immediate Effect of Myofascial Release and Deep Friction Massage on Trigger Point Area, Fascia Thickness, Pain, and Range of Motion, in Lumbar Myofascial Pain Syndrome (Japan)

Tokyo, May 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061650) titled 'Comparison of Myofascial Release and Deep Friction Massage for Low Back Myof... Read More


Clinical Trial: Association of epigenetic alterations in inflammatory/anti-inflammatory cytokine and longevity-related genes with complications and prognosis in patients with chronic kidney disease (Japan)

Tokyo, May 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061635) titled 'Association of DNA methylation of inflammatory, anti-inflammatory, and longe... Read More


Clinical Trial: Effects of Time-of-Day Caffeine Intake on Micturition and Sleep in Healthy Adults (Japan)

Tokyo, May 22 -- UMIN Clinical Trials Registry (UMIN-CTR) received information related to the study (UMIN000061336) titled 'Effects of Time-of-Day Caffeine Intake on Micturition and Sleep in Healthy A... Read More


Singapore Clinical Trial: A Multicenter, Multi-Part, Phase 1/2 Study of EIK1005 as Monotherapy and in Combination with Pembrolizumab in Participants with Advanced Solid Tumors, including Participants with Microsatellite Instability High (MSI-H) or Mismatch Repair Deficient (dMMR) Tumors

Singapore, May 21 -- The Health Sciences Authority received information related to the study titled 'A Multicenter, Multi-Part, Phase 1/2 Study of EIK1005 as Monotherapy and in Combination with Pembro... Read More


Singapore Clinical Trial: A Phase 3, Randomized, Double-Blind, Placebo-controlled, Multicenter, Parallel-group Study to Evaluate the Efficacy and Safety of Once Daily Treprostinil Palmitil Inhalation Powder in Participants with Pulmonary Arterial Hypertension (PALM-PAH)

Singapore, May 21 -- The Health Sciences Authority received information related to the study titled 'A Phase 3, Randomized, Double-Blind, Placebo-controlled, Multicenter, Parallel-group Study to Evalu... Read More


Singapore Clinical Trial: A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and Efficacy of Efimosfermin Alfa in Participants With Biopsy-Confirmed F2- or F3-Stage Metabolic Dysfunction-Associated Steatohepatitis (MASH) (ZENITH-1)

Singapore, May 21 -- The Health Sciences Authority received information related to the study titled 'A Phase 3, Randomized, Double-Blind, Placebo-Controlled, 3-Arm Study to Investigate the Safety and ... Read More