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Singapore Clinical Trial: DAREON®-Lung 1: A Phase III multi-center, open-label, randomised trial of intravenous obrixtamig in combination with atezolizumab, carboplatin, and etoposide vs. atezolizumab, carboplatin, and etoposide as first-line treatment in patients with extensive-stage small cell lung cancer

Singapore, Oct. 15 -- The Health Sciences Authority received information related to the study titled 'DAREON®-Lung 1: A Phase III multi-center, open-label, randomised trial of intravenous obrixtamig i... Read More


Singapore Clinical Trial: An open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and efficacy of BAY 3771249 as monotherapy or combination with other cancer treatments in participants with solid tumors harboring a KRAS G12D mutation

Singapore, Oct. 15 -- The Health Sciences Authority received information related to the study titled 'An open-label study to evaluate the safety, tolerability, pharmacokinetics, pharmacodynamics, and ... Read More


Singapore Clinical Trial: A phase II, multicenter, open-label, single arm study to evaluate the safety and efficacy of asciminib in pediatric participants newly diagnosed or previously treated with Philadelphia positive Chronic Myelogenous Leukemia in Chronic Phase (Ph+ CML-CP) with or without known T315I mutation.

Singapore, Oct. 15 -- The Health Sciences Authority received information related to the study titled 'A phase II, multicenter, open-label, single arm study to evaluate the safety and efficacy of ascim... Read More


Singapore Clinical Trial: A multi-center, open-label, phase I/II study to evaluate the safety and efficacy of asciminib with chemotherapy followed by asciminib plus blinatumomab in pediatric, adolescent, and young adult participants with relapsed or refractory BCR::ABL1-positive (Philadelphia positive, Ph+) or BCR::ABL1-like (Ph-like) acute lymphoblastic leukemia (ALL)

Singapore, Oct. 15 -- The Health Sciences Authority received information related to the study titled 'A multi-center, open-label, phase I/II study to evaluate the safety and efficacy of asciminib with... Read More


Singapore Clinical Trial: A Phase III, multisite, randomized, double-blind trial of BNT327 in combination with chemotherapy versus placebo with chemotherapy in patients with previously untreated locally recurrent inoperable or metastatic TNBC determined ineligible for PD(L)1 therapy based on PD-L1 negative disease

Singapore, Oct. 15 -- The Health Sciences Authority received information related to the study titled 'A Phase III, multisite, randomized, double-blind trial of BNT327 in combination with chemotherapy ... Read More


Clinical Trial: Radicle GI HealthTM VKP: A Study Assessing the Impact of Health and Wellness Products on Gastrointestinal-related Quality of Life and Related Health Outcomes

U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07873216) titled 'Radicle GI HealthTM VKP: A Study Assessing the Impact of Health and Wellness Products on Ga... Read More


Clinical Trial: Follow-up of Pediatric Patients Affected by Primary Hyperoxaluria Type 1 (PH1) Treated With Lumasiran

U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07874074) titled 'Follow-up of Pediatric Patients Affected by Primary Hyperoxaluria Type 1 (PH1) Treated With... Read More


Clinical Trial: HR20013 for the Prevention of Nausea and Vomiting in Patients With Cancer: A Real-World Study

U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07874308) titled 'HR20013 for the Prevention of Nausea and Vomiting in Patients With Cancer: A Real-World Stu... Read More


Clinical Trial: The PSP Alcohol Reset Course

U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07873684) titled 'The PSP Alcohol Reset Course' on Sept. 21. Brief Summary: This observational study evaluat... Read More


Clinical Trial: Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells

U.S., Oct. 15 -- ClinicalTrials.gov registry received information related to the study (NCT07873047) titled 'Acute Effects of Caffeine on Mitochondrial Function in Peripheral Blood Mononuclear Cells' ... Read More